EP4 prostanoid receptor-mediated vasodilatation of human middle cerebral arteries
نویسندگان
چکیده
منابع مشابه
Role of the prostanoid EP4 receptor in iloprost-mediated vasodilatation in pulmonary hypertension.
RATIONALE Iloprost is effective for the treatment of pulmonary hypertension. It acts through elevation of cAMP by binding to the prostacyclin receptor (IP receptor). However, there is evidence that patients with severe pulmonary hypertension have decreased expression of the IP receptor in the remodeled pulmonary arterial smooth muscle. OBJECTIVES We hypothesized that prostanoid receptors othe...
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متن کاملThe prostanoid EP4 receptor and its signaling pathway.
The EP4 prostanoid receptor is one of four receptor subtypes for prostaglandin E2. It belongs to the family of G protein-coupled receptors. It was originally identified, similar to the EP2 receptor as a G(s)α-coupled, adenylyl cyclase-stimulating receptor. EP4 signaling plays a variety of roles through cAMP effectors, i.e., protein kinase A and exchange protein activated by cAMP. However, emerg...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 2004
ISSN: 0007-1188
DOI: 10.1038/sj.bjp.0705645